The regulating effect of naringin on blood lipids is mainly reflected in the following aspects:
1. Reduce low-density lipoprotein cholesterol (LDL-C)
Naringin can significantly reduce low-density lipoprotein cholesterol (LDL-C) levels. LDL-C is the “bad” cholesterol, and high levels can lead to an increased risk of atherosclerosis. Naringin reduces the synthesis and accumulation of LDL-C by regulating the normal expression of lipid metabolism-related proteins (such as PCSK9. LDL-R), thereby reducing its concentration in the blood.
2. Increase high-density lipoprotein cholesterol (HDL-C)
Naringin also helps increase high-density lipoprotein cholesterol (HDL-C) levels. HDL-C is “good” cholesterol, which can transport cholesterol in the blood back to the liver for metabolism and excretion, thereby reducing the risk of cardiovascular disease. Naringin increases the content of HDL-C in the blood by promoting its synthesis and secretion.
3. Regulate blood lipid metabolism pathways
Naringin can regulate the GALNT2-ANGPTL3 blood lipid metabolism pathway, which is one of the key pathways for regulating blood lipid levels. By affecting the expression of genes and proteins related to this pathway, naringin can improve blood lipid status and prevent the occurrence of cardiovascular diseases.
4. Other related functions
In addition to directly regulating blood lipid levels, naringin also has antioxidant, anti-inflammatory and other pharmacological effects, which also help protect cardiovascular health. For example, naringin can scavenge free radicals in the body, reduce oxidative stress reactions, and protect cells from damage; at the same time, it can also inhibit inflammatory reactions and reduce tissue damage caused by inflammation.