1. Enhance venous tension
Diosmin can enhance the tension of the venous wall and enhance the contraction force of venous smooth muscle cells, thereby maintaining the relative stability of the inner diameter of the blood vessels and reducing vascular dilation and tortuosity. This effect helps to reduce blood congestion in the veins, relieve the symptoms of venous insufficiency, and thus improve microcirculation.
2. Reduce capillary permeability
Diosmin can reduce the adhesion and migration of leukocytes and vascular endothelial cells, reduce the release of inflammatory substances (such as histamine, bradykinin, complement, leukotrienes, prostaglandins, excessive free radicals, etc.) after disintegration, and thus reduce the permeability of capillaries. This effect helps to reduce capillary exudation, improve the blood supply and nutrient metabolism of local tissues, thereby reducing inflammatory reactions, promoting tissue repair and wound healing.
3. Promote lymphatic return
Diosmin can improve lymphatic circulation, increase the speed of lymphatic drainage and the contraction of lymphatic vessels, thereby accelerating the return of interstitial fluid and reducing edema. The improvement of the lymphatic system helps to smooth microcirculation and further promote the exchange of blood and tissue fluid.
4. Reduce blood viscosity
Diosmin also has the effect of reducing blood viscosity, which can speed up blood flow and improve microcirculatory stasis. This effect helps to reduce microcirculatory disorders and improve the exchange efficiency of blood and tissue fluid.
Diosmin improves microcirculation in many ways, such as enhancing venous tension, reducing capillary permeability, promoting lymphatic return, and reducing blood viscosity. These effects jointly promote the smooth exchange of blood and tissue fluid, and help alleviate various symptoms caused by microcirculatory disorders. In clinical practice, diosmin is often used to treat diseases such as venous insufficiency, hemorrhoids, and varicose veins, and its effect in improving microcirculation has been widely recognized.