1. Characteristics of L-Rhamnose Monohydrate
L-Rhamnose Monohydrate, also known as 6-deoxy-L-mannose, is an organic compound with a molecular formula of C6H12O5. It is widely found in plant polysaccharides, glycosides, plant gums and bacterial polysaccharides, and its sweetness is 33% of sucrose. This monosaccharide is passively absorbed from the intestine in the human body without a large amount of metabolism and is excreted into the urine in an unchanged form, so its excretion amount is directly related to the amount absorbed from the intestine.
2. Principle of L-Rhamnose Monohydrate determination of intestinal permeability
Intestinal permeability analysis usually uses large-sized oligosaccharides (such as lactulose) and small-sized sugars (such as rhamnose) as probes. When the intestinal barrier function is normal, large molecules (such as lactulose) are not easy to pass through the intestinal barrier, while small molecules (such as rhamnose) are relatively easy to pass through. However, when the intestinal barrier function is impaired, large molecules can also pass through the intestinal barrier into the circulation and be detected in the urine after renal excretion. By measuring the concentration ratio of lactulose and rhamnose in urine, the permeability of the intestinal barrier can be reflected.
3. Application of L-Rhamnose Monohydrate in determining intestinal permeability
Evaluating intestinal permeability: L-Rhamnose Monohydrate is used together with probes such as lactulose to evaluate the intestinal permeability of different parts, including the gastroduodenum, small intestine and large intestine. This method has a certain reference value for diagnosing intestinal diseases such as Crohn’s disease and celiac disease.
Monitoring intestinal health: By regularly measuring intestinal permeability, the intestinal health status can be monitored, abnormal changes in intestinal barrier function can be detected in time, and a basis for the prevention and treatment of intestinal diseases can be provided.